MARC details
000 -LEADER |
fixed length control field |
02208cam a22002895a 4500 |
001 - CONTROL NUMBER |
control field |
017472678 |
003 - CONTROL NUMBER IDENTIFIER |
control field |
Uk |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20181031123521.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
150717s2016 enka frb 001 0 eng d |
015 ## - NATIONAL BIBLIOGRAPHY NUMBER |
National bibliography number |
GBB5A6276 |
Source |
bnb |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
Cancelled/invalid ISBN |
9780081000984 (hbk.) |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
StDuBDS |
Language of cataloging |
eng |
Transcribing agency |
StDuBDS |
Modifying agency |
Uk |
-- |
EG-ScBUE |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
Classification number |
615.19 |
Item number |
HON |
Edition number |
22 |
100 1# - MAIN ENTRY--PERSONAL NAME |
Personal name |
Hongmao, Sun. |
9 (RLIN) |
41857 |
245 12 - TITLE STATEMENT |
Title |
A practical guide to rational drug design / |
Statement of responsibility, etc |
Sun Hongmao. |
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
Place of publication, distribution, etc |
Cambridge ; |
-- |
Waltham, MA : |
Name of publisher, distributor, etc |
Woodhead Publishing / Elsevier, |
Date of publication, distribution, etc |
c.2016. |
300 ## - PHYSICAL DESCRIPTION |
Extent |
275 p. : |
Other physical details |
ill. (col.) ; |
Dimensions |
24 cm. |
490 0# - Series Statement |
Series statement |
Woodhead Publishing series in biomedicine ; |
Volume/sequential designation |
no. 81 |
505 0# - FORMATTED CONTENTS NOTE |
Title |
PART I Rational Drug Design 1. Structure of the target is available 2. Structure of the target is unavailable 3. Virtual screening (VS) |
-- |
PART II Chemoinformatics 1. QSAR modeling 2. Processing HTS results 3. Delivering modeling results |
520 ## - SUMMARY, ETC. |
Summary, etc |
This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes. |
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name as entry element |
Drugs |
General subdivision |
Design. |
Source of heading or term |
BUEsh |
9 (RLIN) |
30136 |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Source of heading or term |
BUEsh |
653 ## - INDEX TERM--UNCONTROLLED |
Resource For college |
Pharmacy |
-- |
Generalities |
Arrived date list |
October2018 |
655 ## - INDEX TERM--GENRE/FORM |
Form subdivision |
Reading book |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
Display text |
Print version: |
International Standard Book Number |
9780081000984 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
Dewey Decimal Classification |